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Dec 21, 1984 · α 2-Macroglobulin (α 2 M) is one of the major cadmium-binding proteins of human plasma. As determined with equilibrium dialysis, α 2 M bound 4.6 (±0.7) mol Cd 2+ per mol protein with an apparent dissociation constant of (9.6 (±5.0))·10 −7 M. Methylamine-modified α 2 M (α 2 M-Me) had a similar affinity for Cd 2+ (K d,app = 5.3·10 −7 M, but fewer binding sites.
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